The new workflow was adapted from an enzymatic DNA tagging technology, DNA-TAG, previously developed in the Devaraj lab. In ...

Gene therapy holds the promise of preventing and curing disease by manipulating gene expression within a patient's cells. However, to be effective, the new gene must make it into a cell's nucleus. The ...

A recent international research project has used advanced microscopy techniques and computational modeling to discover why ...

A research group is the first in the world to succeed in constructing artificial cell nuclei by injecting purified DNA solution instead of sperm into living mouse eggs. Their findings are published in ...

Researchers at the Francis Crick Institute have shown that the 'pacemaker' controlling yeast cell division lies inside the nucleus rather than outside it, as previously thought. Having the pacemaker ...

Cancer cells are subjected to high mechanical pressure that leads to a rupture of the nuclear envelope when migrating through narrow tissue structures, as in the case of metastasis. DNA would normally ...

DNA, though tightly packed in the nucleus, is constantly threatened by damage from metabolism and external stressors. One particularly severe form of DNA damage is the so-called DNA–protein crosslinks ...

(Nanowerk News) Imagine trying to poke a hole in the yolk of a raw egg without breaking the egg white. It sounds impossible, but researchers at the University of California San Diego have developed a ...