Particle therapy, including proton and carbon ion radiotherapy, represents a major advancement in cancer treatment due to its ...

DNA, though tightly packed in the nucleus, is constantly threatened by damage from metabolism and external stressors. One particularly severe form of DNA damage is the so-called DNA–protein crosslinks ...

If severe DNA damage is not repaired, the consequences for the health of cells and tissues are dramatic. A study led by ...

We performed whole-transcriptome sequencing (n = 188) and exon capture DNA sequencing (n = 208) on pretreatment tumors from the CALGB 90601 randomized trial of gemcitabine/cisplatin plus bevacizumab ...

Histopathologic and demographic features of non-small cell lung cancer in patients with BRCA pathogenic germline variants. This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I. This ...

DNA can sustain serious injuries called double strand breaks, in which both strands of the helix snap. These breaks are among the most dangerous forms of DNA damage and immediately trigger the cell's ...

Although DNA is tightly packed and protected within the cell nucleus, it is constantly threatened by damage from normal ...

The FDA has granted orphan drug designation (ODD) to LP-284, a next-generation acylfulvene small molecule, for the treatment of soft tissue sarcomas (STS). This is the third orphan designation for ...

DNA is often described as the instruction manual for building the fundamental components of life. Proteins are helpers that aid DNA in carrying out essential processes such as replication, repair, and ...