Gene targeting is the process of altering a specific sequence or gene at its location in a genome. Potential modifications include deletion, insertion or replacement of endogenous sequence with ...

PSEN1 encodes presenilin-1, a subunit of γ-secretase, the aspartyl protease responsible for Aβ generation. More than 300 mutations in PSEN1 have been reported and mutations in PSEN1 are the most ...